Antiemetics 🤢
Reference guide for antiemetics. Drug table, dosing, indications, and prescribing for nausea and vomiting management.
Antiemetic Medications
Reference table for nausea and vomiting management
| Drug | Dose | Frequency | Route | Indication | Notes | Hepatic | Renal |
|---|---|---|---|---|---|---|---|
| Cyclizine | 50mg | TDS | PO/IM/IV/SC | PON&V, Abdominal causes, Opioid induced | Glaucoma, BPH, delayed gastric emptying, heart failure | No change | No change |
| Ondansetron | 4–8mg | TDS | PO/ SC/ IV/ SL | Chemoradiotherapy, Post-op, GI | QT prolongation, constipation | Max 8mg/day | No change |
| Metoclopramide | 10mg | TDS | PO/IM/IV/PR | Delayed gastric emptying, PON&V | Bowel obstruction, EPS - avoid in Parkinson's disease, QT prolongation, Orthostatic hypotension | No change | Reduce in line with GFR |
| Prochlorperazine | 5–10mg | TDS | PO, IM, IV, PR | Chemo, PONV, Migraine, Vertigo | EPS - avoid in Parkinson's disease, QT prolongation, Orthostatic hypotension | Avoid | Reduce in line with GFR |
Cyclizine
PO/IM/IV/SCDose:50mg
Frequency:TDS
Hepatic:No change
Renal:No change
Indication: PON&V, Abdominal causes, Opioid induced
Notes: Glaucoma, BPH, delayed gastric emptying, heart failure
Ondansetron
PO/ SC/ IV/ SLDose:4–8mg
Frequency:TDS
Hepatic:Max 8mg/day
Renal:No change
Indication: Chemoradiotherapy, Post-op, GI
Notes: QT prolongation, constipation
Metoclopramide
PO/IM/IV/PRDose:10mg
Frequency:TDS
Hepatic:No change
Renal:Reduce in line with GFR
Indication: Delayed gastric emptying, PON&V
Notes: Bowel obstruction, EPS - avoid in Parkinson's disease, QT prolongation, Orthostatic hypotension
Prochlorperazine
PO, IM, IV, PRDose:5–10mg
Frequency:TDS
Hepatic:Avoid
Renal:Reduce in line with GFR
Indication: Chemo, PONV, Migraine, Vertigo
Notes: EPS - avoid in Parkinson's disease, QT prolongation, Orthostatic hypotension