Antiemetics 🤢
Reference guide for antiemetics including ondansetron (Zofran), cyclizine, metoclopramide, and prochlorperazine. Drug table, dosing, indications, and prescribing for nausea and vomiting management.
Antiemetic Medications
Reference table for nausea and vomiting management
| Drug | Dose | Frequency | Route | Indication | Notes | Hepatic | Renal |
|---|---|---|---|---|---|---|---|
| Cyclizine | 50mg | TDS | PO/IM/IV/SC | PON&V, Abdominal causes, Opioid induced | Glaucoma, BPH, delayed gastric emptying, heart failure | No change | No change |
| Ondansetron | 4–8mg | TDS | PO/ SC/ IV/ SL | Chemoradiotherapy, Post-op, GI | QT prolongation, constipation | Max 8mg/day | No change |
| Metoclopramide | 10mg | TDS | PO/IM/IV/PR | Delayed gastric emptying, PON&V | Bowel obstruction, EPS - avoid in Parkinson's disease, QT prolongation, Orthostatic hypotension | No change | Reduce in line with GFR |
| Prochlorperazine | 5–10mg | TDS | PO, IM, IV, PR | Chemo, PONV, Migraine, Vertigo | EPS - avoid in Parkinson's disease, QT prolongation, Orthostatic hypotension | Avoid | Reduce in line with GFR |
Cyclizine
PO/IM/IV/SCDose:50mg
Frequency:TDS
Hepatic:No change
Renal:No change
Indication: PON&V, Abdominal causes, Opioid induced
Notes: Glaucoma, BPH, delayed gastric emptying, heart failure
Ondansetron
PO/ SC/ IV/ SLDose:4–8mg
Frequency:TDS
Hepatic:Max 8mg/day
Renal:No change
Indication: Chemoradiotherapy, Post-op, GI
Notes: QT prolongation, constipation
Metoclopramide
PO/IM/IV/PRDose:10mg
Frequency:TDS
Hepatic:No change
Renal:Reduce in line with GFR
Indication: Delayed gastric emptying, PON&V
Notes: Bowel obstruction, EPS - avoid in Parkinson's disease, QT prolongation, Orthostatic hypotension
Prochlorperazine
PO, IM, IV, PRDose:5–10mg
Frequency:TDS
Hepatic:Avoid
Renal:Reduce in line with GFR
Indication: Chemo, PONV, Migraine, Vertigo
Notes: EPS - avoid in Parkinson's disease, QT prolongation, Orthostatic hypotension