Anticoagulation Meds 💉
Reference guide for anticoagulation medications. Tinzaparin dosing tool (Rotherham chart), drug table, and prescribing for anticoagulation and antiplatelet therapy.
💊 Anticoagulants & Antiplatelets
- Includes common medications used for anticoagulation and antiplatelet therapy in hospital settings.
- Refer to renal and hepatic considerations when prescribing.
- Use the tinzaparin dosing tool below for weight-based VTE prophylaxis and treatment (Rotherham chart).
- Use the enoxaparin dosing calculator on web for Clexane prophylaxis and treatment (HSE NCG-VTE).
Tinzaparin dosing
Rotherham tinzaparin dose chartIf <20, prophylaxis uses the renal weight table; treatment adds haematology advice (per chart).
Enter weight to see suggested doses.
Guidance only. Numbers mirror the NHS Rotherham chart; product SPC, local formulary, and specialist advice take precedence (pregnancy, extremes of weight, RRT).
Weight bands (reference)
Highlighted row matches your inputs above.
VTE prophylaxis — standard (creatinine clearance ≥20 ml/min)
- <50 kg3,500 IUOD
- 50–90 kg4,500 IUOD
- 91–130 kg3,500 IUBD
- 131–170 kg4,500 IUBD
- >170 kg7,000 IUBD
VTE prophylaxis — renal impairment (creatinine clearance <20 ml/min)
If weight is below 31 kg, this table does not define a dose — seek advice.
- 31–49 kg2,500 IUOD
- 50–99 kg4,500 IUOD
- 100–149 kg3,500 IUBD
- ≥150 kg4,500 IUBD
VTE treatment
- ≤30 kg50 IU/kg (nearest 50 IU)Once daily — discuss haematology
- <40 kg or ≥155 kg175 × weight (IU, nearest 50 IU)Once daily
- 40–49 kg8,000 IUOD
- 50–59 kg10,000 IUOD
- 60–69 kg12,000 IUOD
- 70–84 kg14,000 IUOD
- 85–94 kg16,000 IUOD
- 95–109 kg18,000 IUOD
- 110–119 kg20,000 IUOD
- 120–129 kg22,000 IUOD
- 130–139 kg24,000 IUOD
- 140–154 kg26,000 IUOD
Anticoagulation Medications
Reference table for anticoagulation therapy
| Drug | Dose | Frequency | Route | Notes |
|---|---|---|---|---|
| Enoxaparin | 20-40mg | OD | SC | 40mg OD standard dose. 40mg BD if BMI >40 or >120kg. 20mg for low risk or GFR <30. |
| Tinzaparin | 3500-4500iu | OD | SC | VTE prophylaxis <100kg. More useful for outpatient settings. |
| Aspirin | 75-300mg | OD | PO | 75mg stent protection. 300mg for MI/CVA. |
| Clopidogrel | 75-600mg | OD | PO | |
| Prasugrel | 5-60mg | OD | PO | PCI: 60mg load, 10mg maintenance. 5mg if <60kg. Avoid if prior TIA/stroke. |
| Rivaroxaban | 20mg | OD | PO | GFR 30-49: 15mg. GFR <30: do not use. |
| Edoxaban | 60mg | OD | PO | Cr 15-50 OR <60kg OR inhibitors: 30mg. |
| Apixaban | 2.5-5mg | BD | PO | Use 2.5mg BD if two of: Creat >133, Age >80, Weight <60kg. GFR 15-30: 2.5mg BD. |