Enoxaparin dosing (Clexane) 💉
Enoxaparin (Clexane) dosing calculator for VTE prophylaxis and treatment: weight and CrCl-based doses aligned to HSE NCG-VTE and common Irish ward practice.
Enoxaparin (Clexane) dosing
HSE NCG-VTE guidelineUse Cockcroft–Gault for dose adjustment; eGFR is not equivalent.
Enter weight to see suggested doses.
Guidance only. Prophylaxis table reflects common Irish ward practice; treatment per HSE NCG-VTE. Product SPC, local formulary, and specialist advice take precedence.
Prophylaxis reference table
Weight band × creatinine clearance. Highlighted dose matches your inputs above.
Creatinine clearance
>30 ml/min
- <50 kg20 mgOD
- 50–100 kg40 mgOD
- 101–150 kg40 mgBD
- >150 kg60 mgBD
Creatinine clearance
15–30 ml/min
- <50 kg20 mgOD
- 50–100 kg20 mgOD
- 101–150 kg40 mgOD
- >150 kg60 mgOD
Creatinine clearance
<15 ml/min
- <50 kgConsultant
- 50–100 kg20 mgOD
- 101–150 kg20 mgOD
- >150 kgConsultant
ODOnce dailyBDTwice dailyConsultantSeek senior advice
📖 Overview
- Enoxaparin is the most commonly used LMWH in Irish hospitals for VTE prophylaxis and treatment.
- Use Cockcroft–Gault creatinine clearance for dose adjustment — eGFR is not equivalent.
- Always complete a VTE risk assessment and check bleeding risk before prescribing.
💊 Prophylaxis (summary)
- Doses depend on weight band and CrCl — see calculator and reference table.
- Typical standard prophylaxis: 40 mg once daily for 50–100 kg if CrCl >30 ml/min.
- Higher weights and renal impairment use reduced or less frequent dosing — calculator applies the weight/CrCl table.
💉 Treatment (summary)
- CrCl ≥30 ml/min: 1 mg/kg twice daily OR 1.5 mg/kg once daily — select based on thrombotic vs bleeding risk (HSE NCG-VTE).
- CrCl 15–30 ml/min: 1 mg/kg once daily and seek specialist advice.
- CrCl <15 ml/min: no standard dose — consultant / haematology input.
- Treatment doses are rounded to the nearest 10 mg in the calculator — verify with pharmacy and local protocol.
⚠️ Before prescribing
- Check platelets, renal function, weight, active bleeding, and heparin allergy / HIT history.
- Review concurrent anticoagulants, neuraxial procedures, and perioperative plans.
- Document indication, intended duration, and plan for transition to oral anticoagulation where appropriate.
🔗 Related
Disclaimer
- Educational aid only. Prescribing remains your professional responsibility; confirm every dose with local policy, the product SPC (HPRA), and specialist advice where needed.
Note Template
Ready-to-use clinical note structure
🕒 23 / 08 / 2026 — 03:01 ATRP re: enoxaparin (Clexane) Patient: [age] [sex] Admission Dx: [reason for admission] PMHx: [VTE, bleeding, renal disease] 🧾 Hx: • Indication: [VTE prophylaxis / DVT / PE treatment] • Weight: [__] kg · CrCl: [__] ml/min (Cockcroft–Gault) • Bleeding risk / contraindications reviewed: [yes/no] 📋 Plan: • Enoxaparin [__] mg [OD / BD] subcutaneous • VTE risk assessment completed • Duration: [__] — transition to DOAC/warfarin if treatment • Anti-Xa / haematology review: [if indicated] 👤 [Your Name], [Role] IMC: _______